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Job Code: 3182539

We are seeking highly motivated and organized individuals to work on the clinical research projects in the Clinical and Translational Epidemiology Unit at MGH.  The CTEU and the Division of Gastroenterology are research units within the Department of Medicine. The Chan Laboratory’s mission is to advance epidemiologic investigation for the translation of discoveries into effective clinical interventions. Specifically, we are looking for someone to assist in our ongoing clinical trials in the prevention and interception of gastrointestinal diseases, including cancers, and other translational projects related to nutrition, the gut microbiome, and health and disease. All of our studies aim to advance our understanding of the molecular basis of disease with a goal of identifying biomarkers for use in precision medicine.

RESEARCH TECHNICIAN/TECHNOLOGIST

Job Code: Pending (Contact us)

We are seeking highly motivated and organized individuals to work on research projects in the Gastrointestinal Unit laboratory of Dr. Andrew T. Chan. Specifically, we are looking for someone to assist in our ongoing translational research efforts within our clinical trials related to the prevention of gastrointestinal cancers and aspirin chemoprevention. Our studies combine genomics, genetics, proteomics, and cell biology to study the underlying biological mechanisms of aspirin chemoprevention and identify biomarkers for utility in precision medicine.

Job Code: 3164124

The Program Manager will directly report to the CTEU Director of Biobanking under the Unit Chief of the CTEU in their capacities as Principal Investigators.  The candidate will have a broad portfolio of responsibilities.  Working with the Director of Biobanking and the Unit Chief and key stakeholders in the DOM, the candidate will help with activities related to the expansion of DOM investigator-initiated translational biospecimen collection and processing, including the structure and organizational design and development and strategic planning of this DOM wide initiative. Under the general direction of the Unit Chief and Unit faculty, the incumbent will also assist with compiling, copyediting, writing, proofreading, and formatting health, medical, and scientific content for grant requests, progress reports, scientific manuscripts, and visual presentations intended to support the clinical and research goals of this new Core service.  This position requires a broad base of skills in project management, laboratory management, copy writing and editing as well as multi-media content production. The ideal candidate will work fairly independently, receiving minimal supervision.

POST-DOCTORAL RESEARCH FELLOW

July 12, 2023

We consider Postdoctoral Research Fellows on a rolling basis to join research projects investigating mechanistically-informed biomarkers for precision chemoprevention and interception of gastrointestinal (GI) cancers in the laboratories of Andrew T. Chan, MD, MPH and David A. Drew, PhD at Massachusetts General Hospital/Harvard Medical School. As the central laboratory for the Clinical and Translational Epidemiology Unit and housed within the Division of Gastroenterology, the Chan/Drew laboratories are using high-dimensional, multi-omics data and patient-derived translational modeling systems (i.e. intestinal organoids) to interrogate mechanisms of chemoprevention for known anti-cancer agents, including aspirin. The research leverages biospecimens and multi-‘omic data derived from recently completed NCI-sponsored randomized clinical trials (ASPIRED).  Our overarching goal is to define the role of prostaglandin modulation in aspirin chemoprevention, the downstream cellular mechanisms in intestinal epithelial cells, and identify secondary or indirect mechanisms of action mediated by modulation of inflammation or the gut microbiome. In addition, a post-doctoral candidate will gain exposure to and have the opportunity to assist in several ongoing translational research projects including molecular imaging of cathepsins for improving GI cancer detection; a multi-national collaboration funded by Stand Up To Cancer to improve interception for early stage gastric cancer; correlative studies within the Personalized REsponses to DIetary Composition Trials (PREDICT) aimed at advancing precision nutrition recommendations; as well as other projects that are in development. Individual projects will align with existing questions of the research groups and tailored according to the fellow’s background while identifying areas for additional research training. Fellows will also have the opportunity for additional training as needed in partner laboratories within the MGH, HMS, and MIT community.

Candidates should hold a PhD with preference given to applicants with a strong interest in and research training relevant to the areas of cancer prevention, intestinal epithelial cell biology, human genetics/transcriptomics, and the gut microbiome. While not required, bioinformatics, programming and/or statistical skills are a plus.